In high enough doses, opioids can cause breathing to stop completely. Fentanyl’s strength increases this risk of overdose substantially. Synthetic opioids sold illicitly can be mixed with heroin or cocaine, which amplifies its potency and potential danger. This is particularly dangerous if an individual who uses illegal substances like heroin or intentionally misuses prescription drugs is unaware that fentanyl could be in it. Prescription fentanyl is FDA -approved to treat severe pain related to surgery or complex pain conditions.
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This article focuses on injectable fentanyl; more detailed coverage of the transdermal formulation is available in the StatPearls specific article on transdermal fentanyl. Naloxone and naltrexone are opioid antagonists that reverse the effects of fentanyl. Fentanyl is a synthetic opioid that is 50 to 100 times more potent than morphine. It is prescribed to treat severe pain but is also misused and a major contributor to the opioid crisis.
If you are in pain and believe that fentanyl may be an appropriate treatment option for you, talk to your doctor about getting a prescription. I only need to be concerned about fentanyl if I am using certain drugs like heroin. Explore this page to connect with LGBTQ-affirming programs and resources for recovery and support.
Fentanyl: What It Is, Uses, Side Effects & Drug Interactions

OUDs are chronic but treatable medical conditions that involve changes in our brains, which makes stopping very difficult without support. Effective medications that address cravings and withdrawal symptoms, as well as behavioral treatments, can help people with OUDs. One-hundred times more powerful than morphine and 50% more powerful than heroin, fentanyl can be injected, snorted or sniffed, smoked, taken as a pill or placed on paper. Illicitly produced fentanyl is sold alone or combined with heroin and other substances. Because fentanyl is so potent and commonly found in the drug supply, it is easy for people to accidentally overdose on fentanyl. A fentanyl overdose can occur after the drug is injected, swallowed, snorted, or smoked.
Is It Safe To Buy Fentanyl Online?
Illicitly manufactured fentanyl is illegal and can be sold as powder, nasal spray or pills that look like other prescription opioids. Fentanyl can be known by street names such as Apache, China Girl, Dance Fever or Goodfellas. Fentanyl misuse can lead to unconsciousness, compromise respiratory function and lead to overdose resulting in death. A program has been set up for each fentanyl product to decrease the risk of using the medication. Your doctor will need to enroll in the program in order to prescribe fentanyl and you will need to have your prescription filled at a pharmacy that is enrolled in the program.
- Illicit fentanyl is often mixed with other drugs like heroin, cocaine, xylazine, counterfeit prescription pills, or legitimate prescriptions.
- For continuous delivery, a transdermal patch can slowly deliver fentanyl through the skin and into the bloodstream for up to 72 hours.
- A tiny miscalculation can lead to dire consequences, with overdoses resulting in not just life-threatening risks but also potential legal ramifications and mounting medical bills.
- Physical dependence results in withdrawal symptoms when individuals suddenly stop taking the drug.
- Fentanyl can also be “diverted.” That’s when the drug is prescribed by a doctor but isn’t used as directed or is sold or given to someone else.
- Fentanyl patches can take up to 2 days to start working, but they last longer.
Carrying naloxone can provide them with an extra layer of protection from overdose. Alternatively, some people may take illegally manufactured fentanyl for its heroin-like effect. Sometimes, individuals mix it with other drugs because of its potency. Fentanyl is up to 100 times more potent than morphine and 50 times more potent than heroin. You have to handle stressful circumstances when supporting individuals struggling with how easy it is to get illegal substances.
Can A Fentanyl Overdose Be Treated?
Avoid drinking alcohol for several hours after you take fentanyl. Your doctor might prescribe fentanyl if you have severe pain due to cancer, nerve damage, serious injury, or major surgery. Prescription fentanyl is available under such names as Actiq®, Duragesic®, and Sublimaze® in the form of tablets, an injectable liquid, lozenges and patches. Overdose prevention is a CDC priority that impacts families and communities. Drug overdose is a leading cause of preventable death in the U.S. Some people claim they can tell they are taking fentanyl, rather than heroin, due to its pale color (which ranges from bright white to off-white) and sweet taste.
But those low-cost test strips can determine whether a drug contains traces of fentanyl. Discarded fentanyl patches may still contain significant amounts of the drug. This can result in misuse if someone removes the gel contents from discarded patches. They may be available through state and local health departments, syringe services programs, or drug stores and online retailers. Congress passed its first major opioids legislation and funding in late 2016 but hasn’t done much since to follow up.

If A Person Has Naloxone, Is Fentanyl Safe To Use?
People can also unknowingly consume fentanyl when it is mixed into or sold as other drugs, including heroin, cocaine, or counterfeit pills. Fentanyl should only be prescribed by doctors who are experienced in treating pain in cancer patients. Fentanyl may cause serious breathing problems or death if it is used by people who are not being treated with other narcotic medications or who are not tolerant to narcotic medications. Fentanyl exerts its pain-relieving effects by acting on opioid receptors that occur naturally in the body.
How To Tell If Someone Has Overdosed On Fentanyl
Because fentanyl is so potent, a very small dose — the Drug Enforcement Administration (DEA) says just two milligrams — can be lethal. High-potency opioids such as fentanyl, oxycodone (Oxycontin, Roxicodone) and methadone (Methadose, Methadone HCl Intensol) typically have more-serious risks. Fentanyl comes as a lozenge on a handle, a sublingual (underneath the tongue) tablet, and a buccal (between the gum and cheek) tablet to dissolve in the mouth. Fentanyl is used as needed to treat breakthrough pain but not more often than four times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. When it is intentionally misused, fentanyl often shows up as a powder, spiked on blotter paper or is mixed with or substituted for heroin and other street drugs.
A 26-year-old man with a history of fentanyl abuse was found unresponsive in a gas station bathroom. Bystanders administered naloxone and performed CPR until an ambulance arrived. He was taken to a hospital, where he spent 3 days in the intensive care unit.
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Most people need help from a health professional or program to successfully quit. Sometimes people freeze fentanyl patches and cut them into smaller portions. Then they put these small pieces in their cheeks or under their tongue. Dealers may sell it as a standalone drug or as a counterfeit for another drug (like oxycodone). It’s also used as a low-cost additive to other drugs like heroin, methamphetamine, molly, and ecstasy. A sharp increase in deaths from illegal fentanyl use started in 2005 and continued through 2007.

This Is How Easy It Is To Order Deadly Opioids Over The Internet
Illegal fentanyl, however, has an unknown amount of fentanyl and may be mixed with other drugs, which may result in harmful behaviors. Doctors will only prescribe the fentanyl patch to people who are already tolerant of opioid therapy that is similar in strength. Fentanyl can continue to be effective after removing the patch, as the skin has already absorbed the drug. However, the amount of time it remains effective depends on the individual. Over time, however, the brain adapts to fentanyl, making it difficult for someone to experience positive emotions without the drug. Portman and a bipartisan group of senators have actually introduced legislation to require the Postal Service to collect this electronic data.
Research has shown that people who use fentanyl test strips often make changes that can keep them safer. In one study from the Johns Hopkins Bloomberg School of Public Health, 70% of participants said they would change their behavior if they knew the drugs they used contained fentanyl. Fentanyl is a potent and dangerous drug, and the use of drugs without medical supervision carries significant risks. When used, fentanyl quickly binds to opioid receptors in the brain, producing intense feelings of euphoria and pain relief. This effect can lead to both physical and psychological dependence, even with short-term use. Adverse effects occur based on dose, timing, and monitoring.
Overdose Prevention
Another medication, lofexidine, has been approved for treatment of withdrawal symptoms.34 See “Medications for Opioid Use Disorder” for more information. Fentanyl and other synthetic opioids have now surpassed heroin and prescription painkillers as the deadliest drugs in the United States. They killed more than 19,000 Americans in 2016, topping heroin (15,000) and prescription opioids (14,000) for the first time. Fentanyl, regardless of its form, is extremely potent and dangerous. Just two milligrams of fentanyl can be fatal for the average person.

